Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | OGG1 | O15527 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306518 | 1.00 | CNR2 (0.41) | CNR2ADAMTS5KDM4EALDH1A1HPGD | |
| SCHEMBL1307897 | 0.92 | KDM4E (0.46) | CNR2ADAMTS5KDM4EALDH1A1HPGD | |
| SCHEMBL1307895 | 0.92 | KDM4E (0.46) | CNR2ADAMTS5KDM4EALDH1A1HPGD | |
| SCHEMBL1305748 | 0.90 | HDAC1 (0.48) | ADAMTS5KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL29488465 | 0.90 | HDAC1 (0.48) | ADAMTS5KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL1305746 | 0.90 | HDAC1 (0.48) | ADAMTS5KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL1307180 | 0.89 | ALDH1A1 (0.45) | CNR2ADAMTS5KDM4EALDH1A1HPGD | |
| SCHEMBL1307179 | 0.89 | ALDH1A1 (0.45) | CNR2ADAMTS5KDM4EALDH1A1HPGD | |
| SCHEMBL1306520 | 0.84 | ADAMTS5 (0.41) | ADAMTS5KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL22403025 | 0.84 | HTR1B (0.45) | CNR2KDM4EALDH1A1HPGDCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |