Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29153604 | 0.84 | CYP1A2 (0.47) | CYP1A2ALDH1A1CYP3A4TAAR1APLNR | |
| SCHEMBL3397380 | 0.82 | CYP1A2 (0.44) | CYP1A2ALDH1A1CYP3A4TAAR1APLNR | |
| SCHEMBL4964023 | 0.82 | CYP1A2 (0.44) | CYP1A2ALDH1A1CYP3A4TAAR1HSD17B10 | |
| SCHEMBL12925519 | 0.81 | CYP3A4 (0.43) | CYP1A2ALDH1A1CYP3A4KDM4EMEN1 | |
| SCHEMBL25554478 | 0.80 | ALOX5 (0.52) | CYP1A2 | |
| SCHEMBL862161 | 0.79 | ALDH1A1 (0.56) | CYP1A2ALDH1A1CYP3A4HSD17B10CA12 | |
| SCHEMBL10044604 | 0.79 | CYP1A2 (0.46) | CYP1A2ALDH1A1CYP3A4TAAR1HSD17B10 | |
| SCHEMBL10044958 | 0.79 | CYP1A2 (0.65) | CYP1A2ALDH1A1CYP3A4TAAR1HSD17B10 | |
| SCHEMBL28760720 | 0.79 | CYP1A2 (0.46) | CYP1A2ALDH1A1CYP3A4TAAR1HSD17B10 | |
| SCHEMBL14496453 | 0.78 | TAAR1 (0.48) | ALDH1A1CYP3A4TAAR1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017070708-A1 | 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | ARRAY BIOPHARMA, INC. (US) | 2017-04-27 | — | — | WO | disclosed |
| US-20100285407-A1 | Composition for forming a silicon-containing antireflection film, substrate having the silicon-containing antireflection film from the composition and patterning process using the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2010-11-11 | — | — | US | disclosed |