⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27231084 | 0.74 | DGAT1 (0.33) | — | |
| SCHEMBL2886068 | 0.72 | — | — | |
| SCHEMBL2886070 | 0.72 | — | — | |
| SCHEMBL16222535 | 0.69 | — | — | |
| SCHEMBL16222726 | 0.69 | — | — | |
| SCHEMBL15214380 | 0.66 | ALDH1A1 (0.33) | — | |
| SCHEMBL981072 | 0.66 | DGAT1 (0.38) | — | |
| SCHEMBL27500343 | 0.64 | ESR1 (0.43) | — | |
| SCHEMBL2647194 | 0.63 | DGAT1 (0.35) | — | |
| SCHEMBL2632362 | 0.62 | TSHR (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450479-B2 | 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use | PHARMINOX LIMITED (GB) | 2013-05-28 | — | — | US | disclosed |
| US-20100286088-A1 | 3-Substituted-4-Oxo-3,4-Dihydro-Imidazo[5,1-d][1,2,3,5-Tetrazine-8-Carboxylic Acid Amides and Their Use | PHARMINOX LIMITED (GB) | 2010-11-11 | — | — | US | disclosed |
| WO-2009077741-A2 | 3-SUBSTITUTED-4-OXO-3,4-DIHYDRO-IMIDAZO-[5,1-D][1,2,3,5-TETRAZINE-8-CARBOXYLIC ACID AMIDES AND THEIR USE | PHARMINOX LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |