Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14002928 | 0.84 | HRH2 (0.43) | CTSKALDH1A1MAPTJAK3BTK | |
| SCHEMBL2585108 | 0.83 | ALDH1A1 (0.56) | CTSSCTSKALDH1A1MAPTJAK3 | |
| SCHEMBL3626360 | 0.83 | ALDH1A1 (0.56) | CTSSCTSKALDH1A1MAPTJAK3 | |
| SCHEMBL32665591 | 0.82 | NPSR1 (0.53) | ALDH1A1MAPT | |
| SCHEMBL4510174 | 0.80 | PPARG (0.58) | CTSSCTSKALDH1A1MAPTJAK3 | |
| SCHEMBL4092761 | 0.80 | CTSS (0.49) | CTSSCTSKNPC1RAB9AALDH1A1 | |
| SCHEMBL4092754 | 0.80 | CTSS (0.49) | CTSSCTSKNPC1RAB9AALDH1A1 | |
| SCHEMBL4510182 | 0.80 | PPARG (0.58) | CTSSCTSKALDH1A1MAPTJAK3 | |
| SCHEMBL2581127 | 0.78 | ALDH1A1 (0.41) | CTSSCTSKALDH1A1MAPTJAK3 | |
| SCHEMBL9196011 | 0.77 | CTSK (0.50) | CTSSCTSKP2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401433-B1 | AZOLE ACID DERIVATIVES, ALONE OR IN COMBINATION, FOR TREATING DIABETES AND DYSLIPIDEMIAS; AND FOR TREATING MALIGNANT DISEASES | BRISTOL MYERS SQUIBB CO (US) | 2010-11-10 | — | — | EP | disclosed |
| US-7452907-B2 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-18 | — | — | US | disclosed |