Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 17/20 | 0.60 |
| ▸ | NOS3 | P29474 | 16/20 | 0.44 |
| ▸ | NOS2 | P35228 | 3/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | ADA | P00813 | 1/20 | 0.40 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122127 | 0.86 | NOS1 (0.60) | NOS1NOS3NOS2RORCADA | |
| SCHEMBL15499701 | 0.76 | NOS1 (0.47) | NOS1NOS3NOS2 | |
| SCHEMBL1122129 | 0.75 | NOS1 (1.00) | NOS1NOS3NOS2 | |
| SCHEMBL1122204 | 0.73 | NOS1 (0.46) | NOS1NOS3NOS2 | |
| SCHEMBL1122358 | 0.72 | NOS3 (0.60) | NOS1NOS3NOS2 | |
| SCHEMBL14179039 | 0.72 | NOS1 (0.44) | NOS1NOS3NOS2 | |
| SCHEMBL12253664 | 0.71 | NOS1 (0.63) | NOS1NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL1122320 | 0.70 | NOS3 (0.63) | NOS1NOS3NOS2 | |
| SCHEMBL12253663 | 0.70 | NOS3 (0.62) | NOS1NOS3NOS2 | |
| SCHEMBL1121993 | 0.70 | NOS1 (0.42) | NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883451-B1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2010-11-24 | — | — | EP | disclosed |