Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 20/20 | 0.47 |
| ▸ | NOS3 | P29474 | 19/20 | 0.47 |
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122020 | 0.91 | NOS3 (0.60) | NOS1NOS3NOS2 | |
| SCHEMBL1122241 | 0.90 | NOS3 (0.62) | NOS1NOS3NOS2 | |
| SCHEMBL12857014 | 0.90 | NOS1 (0.48) | NOS1NOS3NOS2 | |
| SCHEMBL1122358 | 0.90 | NOS3 (0.60) | NOS1NOS3NOS2 | |
| SCHEMBL1122127 | 0.90 | NOS1 (0.60) | NOS1NOS3NOS2 | |
| SCHEMBL14179039 | 0.90 | NOS1 (0.44) | NOS1NOS3NOS2 | |
| SCHEMBL12253664 | 0.89 | NOS1 (0.63) | NOS1NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL1122320 | 0.88 | NOS3 (0.63) | NOS1NOS3NOS2 | |
| SCHEMBL12253663 | 0.88 | NOS3 (0.62) | NOS1NOS3NOS2 | |
| SCHEMBL12253662 | 0.87 | NOS3 (0.62) | NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682950-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-06-02 | — | — | US | disclosed |
| US-9242957-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-09-11 | — | — | US | disclosed |
| US-8735606-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | NOS1 2/4885NOS3 3/4885NOS2 1/4885 |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | NOS1 2/4885NOS3 3/4885NOS2 1/4885 |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | NOS1 2/4885NOS3 3/4885NOS2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.