Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374136 | 0.91 | PPARG (0.49) | PPARGALDH1A1HPGDPPARDPPARA | |
| SCHEMBL3375295 | 0.85 | PPARA (0.47) | PPARGPPARDPPARAIP6K1IP6K3 | |
| SCHEMBL3376824 | 0.83 | PPARG (0.42) | PPARGPPARDPPARAEPHX2 | |
| SCHEMBL3376160 | 0.80 | PPARG (0.52) | PPARGPPARDPPARA | |
| SCHEMBL10976323 | 0.77 | PPARG (0.52) | PPARGALDH1A1PPARAPTGDR2CYP1A2 | |
| SCHEMBL3376896 | 0.76 | PPARD (0.53) | PPARGPPARDPPARA | |
| SCHEMBL6550208 | 0.74 | PPARG (0.59) | PPARGALDH1A1PPARAPTGDR2CYP1A2 | |
| SCHEMBL13070053 | 0.73 | RAB9A (0.42) | PPARGHPGDPPARDPPARAKDM4E | |
| SCHEMBL3376959 | 0.71 | PPARG (0.46) | PPARGPPARDPPARAPTGDR2 | |
| SCHEMBL3377036 | 0.71 | PPARG (0.47) | PPARGALDH1A1PPARDPPARACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796665-B1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK SHARP & DOHME (US) | 2010-11-17 | — | — | EP | disclosed |