Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 5/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8249373 | 0.90 | DPP4 (0.37) | ALOX15HSD17B10DPP4HDAC4HDAC1 | |
| SCHEMBL12784133 | 0.89 | MEN1 (0.33) | DPP4MEN1 | |
| SCHEMBL8006962 | 0.89 | DPP4 (0.34) | DPP4ADRB3ADRA2BADRA2CMEN1 | |
| SCHEMBL8293914 | 0.86 | ADRB3 (0.45) | ALOX15HSD17B10ADRB3ADRA2BADRA2C | |
| SCHEMBL7940240 | 0.84 | ADRB3 (0.39) | ALOX15HSD17B10ADRB3ADRA2BADRA2C | |
| SCHEMBL13071412 | 0.84 | ADRB3 (0.36) | ALOX15HSD17B10ADRB3ADRA2BADRA2C | |
| SCHEMBL8237929 | 0.83 | DPP4 (0.34) | DPP4 | |
| SCHEMBL11976283 | 0.83 | CTSB (0.41) | HDAC4HDAC1CTSB | |
| SCHEMBL13071881 | 0.83 | CYP3A4 (0.37) | MEN1CTSB | |
| Hydrochloric Acid SCHEMBL1683100 | 0.83 | CTSB (0.41) | CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |