Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 8/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11975940 | 0.90 | HDAC4 (0.33) | MEN1HDAC4HDAC1GAAHSD17B10 | |
| SCHEMBL13071410 | 0.90 | ALOX15 (0.37) | DPP4MEN1HDAC4HDAC1GAA | |
| SCHEMBL8247123 | 0.89 | DPP4 (0.33) | DPP4MEN1HDAC4HDAC1GAA | |
| SCHEMBL8237366 | 0.88 | DPP4 (0.31) | DPP4MEN1HDAC4HDAC1GAA | |
| SCHEMBL14216851 | 0.88 | ALDH1A1 (0.33) | DPP4HDAC4HDAC1GAAHSD17B10 | |
| SCHEMBL8247064 | 0.87 | DPP4 (0.34) | DPP4MEN1GAAHSD17B10ALOX15 | |
| SCHEMBL8223794 | 0.87 | ADRB3 (0.34) | — | |
| SCHEMBL8212674 | 0.87 | ADRB3 (0.34) | — | |
| SCHEMBL8006962 | 0.86 | DPP4 (0.34) | DPP4MEN1GAAKDM4EALDH1A1 | |
| SCHEMBL12784133 | 0.86 | MEN1 (0.33) | DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680137-B1 | Macrocyclic carboxylic acid and acylsulfonamide compound as inhibitor of HCV replication | HOFFMANN LA ROCHE (CH) | 2012-11-21 | — | — | EP | disclosed |
| EP-2305696-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2011038293-A1 | CYCLIC PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-03-31 | — | — | WO | disclosed |
| WO-2007015824-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2007-02-08 | — | — | WO | disclosed |