Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | TRHR | P34981 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12831720 | 0.90 | ACE (0.37) | F2ACEPRSS1PRSS2PRSS3 | |
| SCHEMBL13071413 | 0.88 | TRHR (0.32) | TRHR | |
| SCHEMBL13071426 | 0.88 | HTT (0.37) | TRHR | |
| SCHEMBL13071914 | 0.87 | F2 (0.33) | F2ACEPRSS1PRSS2PRSS3 | |
| SCHEMBL13071629 | 0.86 | ALDH1A1 (0.36) | F2ACEPRSS1PRSS2PRSS3 | |
| SCHEMBL13071627 | 0.86 | ELANE (0.34) | — | |
| SCHEMBL13071403 | 0.85 | USP2 (0.34) | F2ACEPRSS1PRSS2PRSS3 | |
| SCHEMBL12831783 | 0.85 | F2R (0.34) | F2ACEPRSS1PRSS2PRSS3 | |
| SCHEMBL13072075 | 0.85 | XIAP (0.31) | F2F10TRHROPRM1 | |
| SCHEMBL13071626 | 0.84 | DPP4 (0.36) | F2ACEPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |