Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 3/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.32 |
| ▸ | NTSR2 | O95665 | 3/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071403 | 0.92 | USP2 (0.34) | F2RACEF2PRSS1PRSS2 | |
| SCHEMBL13071914 | 0.91 | F2 (0.33) | ACEF2PRSS1PRSS2PRSS3 | |
| SCHEMBL13071629 | 0.91 | ALDH1A1 (0.36) | ACEF2PRSS1PRSS2PRSS3 | |
| SCHEMBL13072075 | 0.91 | XIAP (0.31) | F2OPRM1XIAP | |
| SCHEMBL12831720 | 0.91 | ACE (0.37) | ACEF2PRSS1PRSS2PRSS3 | |
| SCHEMBL13071626 | 0.90 | DPP4 (0.36) | ACEF2PRSS1PRSS2PRSS3 | |
| SCHEMBL13071885 | 0.89 | XIAP (0.35) | F2XIAP | |
| SCHEMBL13071522 | 0.89 | L3MBTL1 (0.36) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL13071408 | 0.88 | XIAP (0.33) | F2RXIAP | |
| SCHEMBL13071525 | 0.88 | CFD (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038293-A1 | CYCLIC PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-03-31 | — | — | WO | disclosed |
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |