Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23795646 | 0.78 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL29841886 | 0.78 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL23795637 | 0.76 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL2410945 | 0.74 | RAB9A (0.56) | KDM4EMAP4K4MITFALDH1A1LMNA | |
| SCHEMBL8162473 | 0.73 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL29841962 | 0.72 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL23795662 | 0.72 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL1730877 | 0.71 | PRKD3 (0.58) | MAPK14MAPK13CSNK1DPRKD3MAP4K4 | |
| SCHEMBL3519701 | 0.70 | MAPK9 (0.58) | MAPK14EGFRCSNK1DPRKD3MAP4K4 | |
| SCHEMBL1730222 | 0.69 | PTGS2 (0.66) | MAPK14MAPK11EGFRCSNK1DPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251343-A1 | IMIDAZOTHIAZOLES AS P38-KINASE-INHIBITORS | ARQULE, INC. (US) | 2010-11-17 | — | — | EP | disclosed |