Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 2/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | TRHR | P34981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13072090 | 0.90 | HTT (0.38) | ACETRHR | |
| SCHEMBL13071524 | 0.88 | HTR1A (0.36) | ACEDPP4TRHR | |
| SCHEMBL13071668 | 0.88 | ACE (0.33) | ACETRHR | |
| SCHEMBL13072094 | 0.87 | USP2 (0.34) | F2RACE | |
| SCHEMBL13071393 | 0.86 | DPP4 (0.32) | F2RDPP4TRHR | |
| SCHEMBL13071425 | 0.86 | ACE (0.38) | ACEDPP4TRHR | |
| SCHEMBL13071878 | 0.86 | XIAP (0.34) | F2RACEDPP4 | |
| SCHEMBL13071521 | 0.82 | CFD (0.39) | — | |
| SCHEMBL12831783 | 0.80 | F2R (0.34) | F2RACE | |
| SCHEMBL13072075 | 0.80 | XIAP (0.31) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |