Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 3/20 | 0.39 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13084696 | 0.81 | HSD11B1 (0.36) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13036385 | 0.81 | HSD11B1 (0.36) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13036382 | 0.81 | HSD11B1 (0.36) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13036284 | 0.78 | MCHR1 (0.33) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13036453 | 0.78 | MCHR1 (0.33) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13036287 | 0.78 | MCHR1 (0.33) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13036413 | 0.78 | PTGER3 (0.38) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13084671 | 0.78 | PTGER3 (0.38) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL13036412 | 0.78 | PTGER3 (0.38) | PER2CRY2MCHR1ADRA1AADRA1B | |
| SCHEMBL2762827 | 0.76 | PTGER3 (0.39) | PER2CRY2ADRA1AADRA1BHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825264-B2 | Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them | SANOFI-AVENTIS (FR) | 2010-11-02 | — | — | US | disclosed |
| US-20080188520-A1 | Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them | SANOFI-AVENTIS (FR) | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188520-A1 | Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them | KCNH1, MLLT3, CYP1A2 | PER2 954/4885CRY2 550/4885MCHR1 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.