Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 19/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075515 | 0.91 | PTGES (0.64) | PTGESMAPK14 | |
| SCHEMBL3793065 | 0.86 | PTGES (0.47) | PTGESMAPK14JAK2 | |
| SCHEMBL3791947 | 0.84 | PTGES (0.61) | PTGESMAPK14JAK2 | |
| SCHEMBL13076252 | 0.82 | PTGES (0.57) | PTGESMAPK14JAK2 | |
| SCHEMBL13075547 | 0.82 | PTGES (0.56) | PTGESMAPK14JAK2 | |
| SCHEMBL13075522 | 0.80 | PTGES (0.65) | PTGESMAPK14 | |
| SCHEMBL13076241 | 0.79 | PTGES (0.55) | PTGESMAPK14JAK2 | |
| SCHEMBL13076280 | 0.78 | PTGES (0.56) | PTGESMAPK14 | |
| SCHEMBL13076254 | 0.78 | PTGES (0.54) | PTGESMAPK14 | |
| SCHEMBL3795330 | 0.78 | PTGES (1.00) | PTGESJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |