Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 15/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799359 | 0.87 | PTGES (0.44) | PTGESKDM1AORAI1MAPK14PIK3CD | |
| SCHEMBL13075522 | 0.81 | PTGES (0.65) | PTGESKDM1APTGS1MAPK14 | |
| SCHEMBL13076254 | 0.81 | PTGES (0.54) | PTGESPTGS1MAPK14PIK3CD | |
| SCHEMBL13075515 | 0.80 | PTGES (0.64) | PTGESKDM1APTGS1MAPK14 | |
| SCHEMBL3791947 | 0.79 | PTGES (0.61) | PTGESPTGS1MAPK14JAK2 | |
| SCHEMBL13075554 | 0.79 | PTGES (0.64) | PTGESMAPK14JAK2 | |
| SCHEMBL13076280 | 0.79 | PTGES (0.56) | PTGESPTGS1MAPK14 | |
| SCHEMBL13076252 | 0.77 | PTGES (0.57) | PTGESPTGS1MAPK14JAK2 | |
| SCHEMBL13075547 | 0.77 | PTGES (0.56) | PTGESPTGS1MAPK14JAK2 | |
| SCHEMBL13076234 | 0.75 | PTGES (0.61) | PTGESPTGS1MAPK14JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |