Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075541 | 0.93 | KDM4E (0.43) | GCGRNPC1ALDH1A1RAB9AP4HTM | |
| SCHEMBL13075525 | 0.92 | MAPK7 (0.43) | GCGRNPC1RAB9ASMN1; SMN2P4HTM | |
| SCHEMBL13075530 | 0.91 | SMN1; SMN2 (0.43) | GCGRNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL13075516 | 0.87 | NPC1 (0.46) | GCGRNPC1RAB9ASMN1; SMN2P4HTM | |
| SCHEMBL13075531 | 0.86 | LMNA (0.50) | GCGRALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL13075532 | 0.86 | GCGR (0.40) | GCGRMAPK7NR2E3MAOBATR | |
| SCHEMBL3795491 | 0.85 | PTGES (0.43) | GCGRP4HTM | |
| SCHEMBL3796557 | 0.84 | PTGES (0.53) | GCGRNPC1ALDH1A1GAARAB9A | |
| SCHEMBL29662800 | 0.82 | PTGES (0.43) | — | |
| SCHEMBL3799056 | 0.81 | PTGES (0.40) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |