Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 8/20 | 0.43 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 5/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075541 | 0.88 | KDM4E (0.43) | PTGESKMOGCGRP4HTM | |
| SCHEMBL13075516 | 0.86 | NPC1 (0.46) | PTGESGCGRP4HTM | |
| SCHEMBL4783219 | 0.86 | TTR (0.55) | PTGESEIF4ETTRDHODHJAK2 | |
| SCHEMBL13076264 | 0.85 | GCGR (0.42) | GCGRP4HTM | |
| SCHEMBL3799056 | 0.84 | PTGES (0.40) | PTGESEIF4EGCGRJAK2 | |
| SCHEMBL13075530 | 0.84 | SMN1; SMN2 (0.43) | PTGESGCGR | |
| SCHEMBL4786153 | 0.84 | EIF4E (0.50) | PTGESEIF4EKMOTTRDHODH | |
| SCHEMBL13075525 | 0.83 | MAPK7 (0.43) | PTGESGCGRP4HTM | |
| SCHEMBL3796320 | 0.83 | PTGES (0.49) | PTGESJAK2 | |
| SCHEMBL13076224 | 0.83 | GCGR (0.43) | PTGESGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |