Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.46 |
| ▸ | ACSS2 | Q9NR19 | 6/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801440 | 0.91 | POLB (0.49) | POLBTLR8 | |
| SCHEMBL19437489 | 0.82 | POLB (0.60) | POLBTLR8ACSS2NOD1LMNA | |
| SCHEMBL24845833 | 0.77 | BRD4 (0.58) | BRD4 | |
| SCHEMBL30163788 | 0.77 | BRD4 (0.58) | BRD4 | |
| SCHEMBL11736204 | 0.75 | PI4KB (0.42) | ACSS2NOD1SMN1; SMN2BRD4 | |
| SCHEMBL21310907 | 0.75 | TLR7 (0.55) | TLR8ACSS2F2RCDK1CDK4 | |
| SCHEMBL11622008 | 0.74 | PI4KB (0.59) | — | |
| SCHEMBL13077024 | 0.74 | ACSS2 (0.48) | POLBTLR8ACSS2BRD4 | |
| SCHEMBL29154862 | 0.73 | BRD4 (0.51) | BRD4 | |
| SCHEMBL24492391 | 0.73 | TLR7 (0.51) | TLR8ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |