Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18631249 | 0.86 | ACSS2 (0.42) | ACSS2TLR8IDH1MAP4K4MAPKAPK2 | |
| SCHEMBL26451964 | 0.85 | EHMT2 (0.48) | ACSS2POLBTLR7GNRHRBACE1 | |
| SCHEMBL3796469 | 0.83 | POLB (0.52) | POLBTLR8CYP1A2CYP2C19RAB9A | |
| SCHEMBL3801440 | 0.81 | POLB (0.49) | POLBTLR8RAB9AKDM4EBACE1 | |
| SCHEMBL1882734 | 0.78 | ACSS2 (0.46) | ACSS2POLBTLR7IDH1MAPKAPK2 | |
| SCHEMBL1890948 | 0.78 | ACSS2 (0.48) | ACSS2POLBTLR7IDH1MAPKAPK2 | |
| SCHEMBL13076395 | 0.77 | POLB (0.45) | POLBTLR8BRD4BACE1 | |
| SCHEMBL3799520 | 0.74 | ACSS2 (0.53) | ACSS2POLBTLR8RAB9AKDM4E | |
| SCHEMBL13076797 | 0.74 | POLB (0.49) | ACSS2POLBTLR8BRD4 | |
| SCHEMBL30782720 | 0.73 | PPARG (0.56) | ACSS2POLBIDH1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |