Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852467 | 0.86 | — | — | |
| SCHEMBL17273342 | 0.68 | — | — | |
| SCHEMBL31296681 | 0.68 | — | — | |
| SCHEMBL4853869 | 0.65 | CDC25A (0.32) | — | |
| SCHEMBL2490555 | 0.63 | MAP3K9 (0.33) | — | |
| SCHEMBL16162853 | 0.63 | — | — | |
| SCHEMBL1102630 | 0.59 | MAPK14 (0.46) | TNF | |
| SCHEMBL349140 | 0.59 | ALDH1A1 (0.30) | — | |
| SCHEMBL4853859 | 0.58 | GPR3 (0.31) | — | |
| SCHEMBL16415808 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074917-A1 | Preparation and Uses of 7-Azaindenoisoquinolines | PURDUE RESEARCH FOUNDATION | 2025-03-06 | — | — | US | disclosed |
| CN-119497715-A | Preparation and application of 7-aza-indeno isoquinoline | 珀杜研究基金会 | 2025-02-21 | — | — | CN | disclosed |
| US-20240287089-A1 | Preparation and Uses of 7-Azaindenoisoquinolines | PURDUE RESEARCH FOUNDATION (US) | 2024-08-29 | — | — | US | disclosed |
| US-9796753-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2017-10-24 | — | — | US | disclosed |
| EP-3112349-A2 | A PROCESS FOR PREPARING N-SUBSTITUTED INDENOISOQUINOLINES | Purdue Research Foundation (US) | 2017-01-04 | — | — | EP | disclosed |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-08-11 | — | — | US | disclosed |
| US-9399660-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2016-07-26 | — | — | US | disclosed |
| EP-1960366-B1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2016-07-20 | — | — | EP | disclosed |
| US-9388211-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2016-07-12 | — | — | US | disclosed |
| US-9217010-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2015-12-22 | — | — | US | disclosed |
| US-20150299246-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2015-10-22 | — | — | US | disclosed |
| US-20150218207-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | NATIONAL INSTITUTES OF HEALTH | 2015-08-06 | — | — | US | disclosed |
| US-20140336188-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2014-11-13 | — | — | US | disclosed |
| US-8829022-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2014-09-09 | — | — | US | disclosed |
| US-20120101119-A1 | N-substituted indenoisoquinolines and syntheses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-04-26 | — | — | US | disclosed |
| US-8053443-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2011-11-08 | — | — | US | disclosed |
| US-20080318995-A1 | N-Substituted Indenoisoquinolines and Syntheses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-25 | — | — | US | disclosed |
| EP-1960366-A2 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | Purdue Research Foundation (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059008-A2 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074917-A1 | Preparation and Uses of 7-Azaindenoisoquinolines | MYC, MYCBP, DNMT1 | TNF 4609/4885 |
| US-20150299246-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | GNAQ, NRAS, NPM1 | TNF 4793/4885 |
| US-20080318995-A1 | N-Substituted Indenoisoquinolines and Syntheses Thereof | GNAQ, NRAS, NPM1 | TNF 4793/4885 |
| US-20120101119-A1 | N-substituted indenoisoquinolines and syntheses thereof | GNAQ, NRAS, NPM1 | TNF 4793/4885 |
| US-20150218207-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | GNAQ, NRAS, NPM1 | TNF 4793/4885 |
| US-20140336188-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | GNAQ, NRAS, NPM1 | TNF 4793/4885 |
| US-20240287089-A1 | Preparation and Uses of 7-Azaindenoisoquinolines | MYC, MYCBP, DNMT1 | TNF 4609/4885 |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | GNAQ, NRAS, NPM1 | TNF 4793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.