Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041381 | 0.92 | TP53 (0.48) | TP53HTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL13622543 | 0.91 | HTT (0.43) | TP53HTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL13041384 | 0.88 | TP53 (0.45) | TP53HTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL3731793 | 0.76 | KDM4E (0.56) | TP53HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL16141009 | 0.73 | CCR2 (0.46) | LMNAALDH1A1MAPTTBXA2RKMT2A | |
| SCHEMBL17457367 | 0.71 | CCR2 (0.51) | LMNAALDH1A1P2RX4MAPTTBXA2R | |
| SCHEMBL3738525 | 0.70 | TP53 (0.38) | TP53HTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6087197 | 0.68 | ALDH1A1 (0.73) | HTTSMN1; SMN2KDM4ELMNAALDH1A1 | |
| SCHEMBL13178171 | 0.68 | CCR2 (0.49) | TP53LMNAALDH1A1P2RX4MAPT | |
| SCHEMBL6086148 | 0.67 | ALDH1A1 (0.52) | HTTKDM4ELMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-7470709-B2 | Benzimidazole quinolinones and uses thereof | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-12-30 | — | — | US | disclosed |