Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 19/20 | 0.84 |
| ▸ | L3MBTL1 | Q9Y468 | 17/20 | 0.84 |
| ▸ | MBTD1 | Q05BQ5 | 6/20 | 0.84 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.84 |
| ▸ | L3MBTL4 | Q8NA19 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14423861 | 0.98 | L3MBTL3 (0.85) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL23682730 | 0.92 | L3MBTL3 (1.00) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL19145583 | 0.91 | L3MBTL3 (0.81) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL23682947 | 0.90 | L3MBTL3 (1.00) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL13731378 | 0.87 | L3MBTL3 (0.72) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL1710098 | 0.86 | L3MBTL3 (0.73) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL23682705 | 0.84 | L3MBTL3 (1.00) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL764630 | 0.84 | L3MBTL3 (0.84) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL23682961 | 0.84 | L3MBTL3 (0.84) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL4489215 | 0.84 | L3MBTL3 (0.88) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180016240-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS | XCOVERY HOLDINGS, INC. | 2018-01-18 | — | — | US | disclosed |
| US-20180016240-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS | XCOVERY HOLDINGS, INC. | 2018-01-18 | — | — | US | disclosed |
| EP-2625176-B1 | SUBSTITUTUTED 6-AMINO-PYRIDAZIN-3-YL-CARBOXAMIDE COMPOUNDS AS PROTEIN KINASE MODULATORS | XCOVERY HOLDING CO LLC (US) | 2016-08-17 | — | — | EP | disclosed |
| US-20160068493-A1 | SUBSTITUTED PYRIDAZINE CARBOXIMIDE COMPOUNDS | XCOVERY HOLDINGS, INC. | 2016-03-10 | — | — | US | disclosed |
| US-20160068493-A1 | SUBSTITUTED PYRIDAZINE CARBOXIMIDE COMPOUNDS | XCOVERY HOLDINGS, INC. | 2016-03-10 | — | — | US | disclosed |
| US-9126947-B2 | Substituted pyridazine carboxamide compounds | XCOVERY HOLDING COMPANY LLC (US) | 2015-09-08 | — | — | US | disclosed |
| US-9126947-B2 | Substituted pyridazine carboxamide compounds | XCOVERY HOLDING COMPANY LLC (US) | 2015-09-08 | — | — | US | disclosed |
| US-20130190298-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS | XCOVERY HOLDING COMPANY, LLC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-20130190298-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS | XCOVERY HOLDING COMPANY, LLC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-8486941-B2 | Phenyl amino pyrimidine compounds and uses thereof | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2013-07-16 | — | — | US | disclosed |
| US-20100291679-A1 | COMPOSITION FOR COLLECTING AND PRESERVING PLACENTAL STEM CELLS AND METHODS OF USING THE COMPOSITION | ANTHROGENESIS CORPORATION | 2010-11-18 | — | — | US | disclosed |
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | GLAXOSMITHKLINE LLC | 2010-08-05 | — | — | US | disclosed |
| US-20070190042-A1 | Composition for collecting and preserving placental stem cells and methods of using the composition | Celularity, Inc. | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | JAK2, JAK1, JAK3 | L3MBTL3 2030/4885L3MBTL1 1843/4885MBTD1 2184/4885 |
| US-20180016240-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS | ALK, MAP4K2, MAP3K15 | L3MBTL3 2318/4885L3MBTL1 1547/4885MBTD1 1721/4885 |
| US-20070190042-A1 | Composition for collecting and preserving placental stem cells and methods of using the composition | PGF, ALPP, CPA1 | L3MBTL3 4106/4885L3MBTL1 3915/4885MBTD1 3757/4885 |
| US-20130190298-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS | ALK, MAP4K2, MAP3K15 | L3MBTL3 2318/4885L3MBTL1 1547/4885MBTD1 1721/4885 |
| US-20160068493-A1 | SUBSTITUTED PYRIDAZINE CARBOXIMIDE COMPOUNDS | ALK, MAP4K2, MAP3K15 | L3MBTL3 2083/4885L3MBTL1 1370/4885MBTD1 1439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.