Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 13/20 | 0.51 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13057673 | 0.86 | PNP (0.45) | PNPHPRT1POLB | |
| SCHEMBL20326990 | 0.80 | PNP (0.46) | PNPHPRT1POLB | |
| SCHEMBL20324724 | 0.78 | PNP (0.45) | PNPHPRT1POLB | |
| SCHEMBL13694795 | 0.78 | TLR7 (0.48) | — | |
| SCHEMBL20324643 | 0.78 | ALDH1A1 (0.45) | PNP | |
| SCHEMBL13082210 | 0.78 | PDE8B (0.42) | POLB | |
| SCHEMBL20324565 | 0.77 | PNP (0.43) | PNPHPRT1POLB | |
| SCHEMBL13415717 | 0.72 | PNP (0.39) | PNPHPRT1POLB | |
| SCHEMBL20324650 | 0.72 | POLB (0.47) | PNPPOLB | |
| SCHEMBL12151598 | 0.72 | HPRT1 (0.61) | PNPHPRT1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842672-B2 | Phosphonate inhibitors of HCV | GILEAD SCIENCES, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-20080107628-A1 | Polymerase inhibitors | GILEAD SCIENCES, INC. | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080107628-A1 | Polymerase inhibitors | POLR2H, POLR2E, POLR1E | PNP 80/4885HPRT1 529/4885POLB 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.