Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308300 | 1.00 | MEN1 (0.45) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL1308081 | 0.91 | SIGMAR1 (0.39) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL1308080 | 0.91 | SIGMAR1 (0.39) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL1308003 | 0.91 | KMT2A (0.48) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL1308006 | 0.91 | KMT2A (0.48) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL1306703 | 0.89 | HDAC1 (0.49) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL1306701 | 0.89 | HDAC1 (0.49) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL29488482 | 0.89 | HDAC1 (0.49) | MEN1KMT2AALDH1A1TSHRHPGD | |
| SCHEMBL1307230 | 0.89 | KDM4E (0.40) | ALDH1A1TSHRHPGDCNR2KDM4E | |
| SCHEMBL1306841 | 0.89 | CNR2 (0.40) | ALDH1A1HPGDCNR2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |