Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308080 | 1.00 | SIGMAR1 (0.39) | SIGMAR1CNR2ALDH1A1PREPCNR1 | |
| SCHEMBL1306839 | 0.97 | CNR2 (0.40) | CNR2ALDH1A1PREPCNR1HPGD | |
| SCHEMBL1306841 | 0.97 | CNR2 (0.40) | CNR2ALDH1A1PREPCNR1HPGD | |
| SCHEMBL1306825 | 0.92 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1PREPMEN1KMT2A | |
| SCHEMBL1306829 | 0.92 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1PREPMEN1KMT2A | |
| SCHEMBL1308300 | 0.91 | MEN1 (0.45) | CNR2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL1308296 | 0.91 | MEN1 (0.45) | CNR2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL1306742 | 0.90 | HDAC1 (0.41) | SIGMAR1ALDH1A1PREPMEN1KMT2A | |
| SCHEMBL29488469 | 0.90 | HDAC1 (0.41) | SIGMAR1ALDH1A1PREPMEN1KMT2A | |
| SCHEMBL1306745 | 0.90 | HDAC1 (0.41) | SIGMAR1ALDH1A1PREPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |