Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434237 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL13923572 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL125673 | 0.98 | ALDH1A1 (0.57) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL11995969 | 0.91 | ALDH1A1 (0.57) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL130814 | 0.91 | ALDH1A1 (0.57) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL17262062 | 0.91 | ALDH1A1 (0.57) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL13107064 | 0.91 | SMN1; SMN2 (0.54) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL14658202 | 0.90 | SMN1; SMN2 (0.58) | ALDH1A1TDP1SMN1; SMN2HTTTHRB | |
| SCHEMBL125382 | 0.90 | — | — | |
| SCHEMBL9426190 | 0.90 | ALDH1A1 (0.52) | ALDH1A1TDP1SMN1; SMN2HTTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111018680-B | Novel cyclopropylmethoxy derivatives | 国际香料和香精公司 | 2023-07-28 | — | — | CN | claimed |
| EP-3636627-B1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INT FLAVORS & FRAGRANCES INC (US) | 2021-12-15 | — | — | EP | claimed |
| US-11111458-B2 | Cyclopropylmethoxy derivatives | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2021-09-07 | — | — | US | claimed |
| CN-111018680-A | Novel cyclopropyl methoxy derivative | 国际香料和香精公司 | 2020-04-17 | — | — | CN | claimed |
| US-20200115652-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2020-04-16 | — | — | US | claimed |
| EP-3636627-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | International Flavors & Fragrances Inc. (US) | 2020-04-15 | — | — | EP | claimed |
| CN-111018680-B | Novel cyclopropylmethoxy derivatives | 国际香料和香精公司 | 2023-07-28 | — | — | CN | disclosed |
| EP-3636627-B1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INT FLAVORS & FRAGRANCES INC (US) | 2021-12-15 | — | — | EP | disclosed |
| EP-3636627-B1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INT FLAVORS & FRAGRANCES INC (US) | 2021-12-15 | — | — | EP | disclosed |
| US-11111458-B2 | Cyclopropylmethoxy derivatives | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-11111458-B2 | Cyclopropylmethoxy derivatives | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2021-09-07 | — | — | US | disclosed |
| CN-111018680-A | Novel cyclopropyl methoxy derivative | 国际香料和香精公司 | 2020-04-17 | — | — | CN | disclosed |
| US-20200115652-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2020-04-16 | — | — | US | disclosed |
| EP-3636627-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | International Flavors & Fragrances Inc. (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-3636627-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | International Flavors & Fragrances Inc. (US) | 2020-04-15 | — | — | EP | disclosed |
| US-8450319-B2 | Pyrrolopyridazinone compound | UBE INDUSTRIES, LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| EP-1982986-B1 | PYRROLOPYRIDAZINONE COMPOUND AS PDE4 INHIBITOR | UBE INDUSTRIES (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20090036453-A1 | Pyrrolopyridazinone Compound | UBE INDUSTRIES, LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1982986-A1 | PYRROLOPYRIDAZINONE COMPOUND | Ube Industries, Ltd. (JP) | 2008-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11111458-B2 | Cyclopropylmethoxy derivatives | TRPA1, TRPV1, CBR3 | ALDH1A1 132/4885TDP1 3994/4885SMN1; SMN2 4715/4885 |
| US-20200115652-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | TRPA1, TRPV1, OR51E2 | ALDH1A1 221/4885TDP1 4237/4885SMN1; SMN2 4660/4885 |
| US-20090036453-A1 | Pyrrolopyridazinone Compound | CBR3, CBR1, CYC1 | ALDH1A1 580/4885TDP1 4125/4885SMN1; SMN2 4613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.