Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.77 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772072 | 0.87 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11398470 | 0.74 | PDE3B (0.73) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL1571023 | 0.74 | PDE3B (0.75) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11278036 | 0.73 | PDE3B (0.71) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL8196489 | 0.72 | PDE3B (0.70) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL9718399 | 0.71 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL14140852 | 0.70 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Bromide SCHEMBL11168072 | 0.70 | PDE3B (0.97) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Quazinone SCHEMBL2463520 | 0.69 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Quazinone SCHEMBL120976 | 0.69 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1949893-B1 | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors | SHIRE BIOPHARMACEUTICALS HOLDI (GB) | 2010-10-13 | — | — | EP | disclosed |
| EP-1949893-A2 | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors | Shire Holdings AG (CH) | 2008-07-30 | — | — | EP | disclosed |