SCHEMBL13085409

SCHEMBL13085409

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.37
NTRK1 P04629 4/20 0.37
MEN1 O00255 3/20 0.36
MALT1 Q9UDY8 1/20 0.35
ALDH1A1 P00352 2/20 0.35
LMNA P02545 2/20 0.35
MAPT P10636 2/20 0.35
DHODH Q02127 2/20 0.35
KDM4E B2RXH2 1/20 0.35
RIPK1 Q13546 1/20 0.35
POLB P06746 1/20 0.35
NPY5R Q15761 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13085454 0.92 KMT2A (0.36) KMT2ANTRK1MEN1ALDH1A1LMNA
SCHEMBL13090544 0.91 KMT2A (0.35) KMT2ANTRK1MEN1ALDH1A1LMNA
SCHEMBL13090573 0.91 CNR2 (0.34) KMT2ANTRK1MEN1ALDH1A1LMNA
SCHEMBL13085384 0.90 F10 (0.34) RIPK1NPY5R
SCHEMBL13090571 0.90 MMP13 (0.31) KMT2ANTRK1MEN1LMNADHODH
SCHEMBL13085472 0.89 MEN1 (0.31) KMT2ANTRK1MEN1NPY5RTSHR
SCHEMBL13085168 0.89 SLC2A1 (0.35) KMT2ANTRK1MEN1ALDH1A1LMNA
SCHEMBL13084945 0.88 L3MBTL1 (0.39) NTRK1ALDH1A1LMNAKDM4EPOLB
SCHEMBL13084903 0.88 NPC1 (0.35) ALDH1A1
SCHEMBL685542 0.87 DHODH (0.33) NTRK1MALT1ALDH1A1DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides ANTXR2, PNISR, H1-5 KMT2A 1624/4885NTRK1 2506/4885MEN1 2128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.