Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 7/20 | 0.47 |
| ▸ | MME | P08473 | 6/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 4/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464310 | 0.85 | NPSR1 (0.50) | NPSR1ACEMMEACE2REN | |
| SCHEMBL12194533 | 0.80 | REN (0.60) | NPSR1ACEREN | |
| SCHEMBL13427297 | 0.79 | HDAC3 (0.55) | ACEMMEACE2CPA1HDAC3 | |
| SCHEMBL13318751 | 0.76 | TACR1 (0.47) | ACEREN | |
| SCHEMBL5180357 | 0.75 | NPSR1 (0.69) | NPSR1ACEMMEACE2CPA1 | |
| SCHEMBL5180354 | 0.75 | NPSR1 (0.69) | NPSR1ACEMMEACE2CPA1 | |
| SCHEMBL8613833 | 0.75 | NPSR1 (0.69) | NPSR1ACEMMEACE2CPA1 | |
| SCHEMBL417751 | 0.74 | REN (0.46) | ACEMMERENHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL7348250 | 0.74 | LAP3 (0.44) | CPA1 | |
| SCHEMBL10408617 | 0.73 | ACE (0.68) | NPSR1ACEMMEACE2CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878720-B1 | Process for preparing chiral bicycloprolinates as intermediates for the preparation of peptidomimetic protease inhibitors | VERTEX PHARMA (US) | 2010-10-06 | — | — | EP | disclosed |