Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 9/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 7/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13087291 | 0.92 | CYP17A1 (0.43) | CYP17A1CYP21A2CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL13090099 | 0.90 | CYP17A1 (0.41) | CYP17A1CYP21A2CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL13087624 | 0.90 | TDO2 (0.47) | PRKCZPRKD2TDO2 | |
| SCHEMBL13089995 | 0.90 | PRKCZ (0.48) | CYP17A1CYP21A2PRKCZPRKD2CNR1 | |
| SCHEMBL13087424 | 0.89 | CSNK1E (0.42) | CYP17A1CYP21A2CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL13087668 | 0.89 | PRKCZ (0.42) | CYP17A1CYP21A2CYP11B1PRKCZPRKD2 | |
| SCHEMBL13100111 | 0.88 | CNR1 (0.37) | CYP17A1CYP21A2CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL13087426 | 0.88 | CNR1 (0.43) | CYP17A1CYP21A2CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL13087292 | 0.87 | CYP17A1 (0.39) | CYP17A1CYP21A2CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL13087490 | 0.87 | CCR6 (0.46) | CYP11B1PRKCZPRKD2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299055-B2 | 8-substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| US-8299055-B2 | 8-substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-10-14 | — | — | US | disclosed |
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | RELA, NFKBIA, NFKB2 | CYP17A1 777/4885CYP21A2 1621/4885CYP3A4 4163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.