Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3352037 | 0.89 | KCNH2 (0.51) | TSHRKDM4EKCNH2POLBTP53 | |
| SCHEMBL89003 | 0.82 | TSHR (0.70) | TSHRRENPOLBTP53MAPT | |
| SCHEMBL18581311 | 0.82 | TSHR (0.55) | TSHRKDM4EPOLBTP53MAPT | |
| SCHEMBL8264865 | 0.81 | REN (0.57) | TSHRKDM4ERENPOLBTP53 | |
| SCHEMBL18581126 | 0.81 | L3MBTL1 (0.51) | TSHRKDM4EKCNH2MAPTTHRB | |
| SCHEMBL3213901 | 0.80 | SMN1; SMN2 (0.56) | TSHRKDM4EKCNH2POLBHSD17B10 | |
| SCHEMBL2240091 | 0.79 | REN (0.50) | TSHRRENTHRB | |
| SCHEMBL2243808 | 0.79 | ALDH1A1 (0.53) | RENPOLBMAPT | |
| SCHEMBL1047741 | 0.79 | REN (0.57) | TSHRKDM4ERENPOLBTP53 | |
| SCHEMBL89401 | 0.79 | TSHR (0.71) | TSHRRENPOLBTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243779-A1 | BICYCLIC HETEROCYCLIC DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-10-27 | — | — | EP | disclosed |