Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.44 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.44 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054752 | 0.84 | HPGDS (0.55) | NPC1CTSDIDO1TDO2CA12 | |
| SCHEMBL10992973 | 0.84 | HMGCR (0.51) | HMGCRCA9 | |
| SCHEMBL878658 | 0.83 | NPC1 (0.64) | HMGCRNPC1CTSDIDO1TDO2 | |
| SCHEMBL29738645 | 0.83 | NPC1 (0.64) | HMGCRNPC1CTSDIDO1TDO2 | |
| SCHEMBL3947925 | 0.82 | MEN1 (0.52) | NPC1CTSDKCNK3KCNK9IDO1 | |
| SCHEMBL11252714 | 0.82 | KDM4E (0.43) | — | |
| SCHEMBL3661643 | 0.82 | HPGD (0.54) | HMGCRNPC1 | |
| SCHEMBL5307288 | 0.82 | HMGCR (0.50) | HMGCRNPC1CTSDCA12CA1 | |
| SCHEMBL28839615 | 0.82 | TAS1R3 (0.57) | HMGCRNPC1CTSD | |
| SCHEMBL8423142 | 0.81 | UTS2R (0.47) | CTSDABCB1KCNK3KCNK9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108484600-A | The URAT1 inhibitor of uricosuric excretion | 江苏新元素医药科技有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-108084186-A | URAT1 inhibitor and its application | 江苏新元素医药科技有限公司 | 2018-05-29 | — | — | CN | disclosed |
| EP-2243779-A1 | BICYCLIC HETEROCYCLIC DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-10-27 | — | — | EP | disclosed |