Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826187 | 0.93 | ALDH1A1 (0.46) | ALDH1A1KMT2AHSD11B1ALKKDM4E | |
| SCHEMBL2824109 | 0.88 | HSD11B1 (0.47) | ALDH1A1KMT2AHSD11B1ALKKDM4E | |
| SCHEMBL2452739 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KMT2AKDM4EPOLBHPGD | |
| SCHEMBL4369091 | 0.83 | TRPV4 (0.47) | ALDH1A1KMT2AHSD11B1TBXA2RVEGFA | |
| SCHEMBL2379501 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KMT2AKDM4EPOLBHPGD | |
| SCHEMBL13679842 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2AKDM4EPOLBHPGD | |
| SCHEMBL13413623 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2AKDM4EPOLBHPGD | |
| SCHEMBL2822547 | 0.81 | NPC1 (0.56) | ALDH1A1KMT2AHSD11B1POLBCCR1 | |
| SCHEMBL13448624 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KMT2AKDM4EPOLBHPGD | |
| SCHEMBL2819983 | 0.79 | TRPV4 (0.40) | ALDH1A1KMT2ATBXA2RVEGFAEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849469-B1 | Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders | AXIKIN PHARMACEUTICALS INC (US) | 2010-10-27 | — | — | EP | disclosed |