Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246383 | 0.87 | CHRNB4 (0.51) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 | |
| SCHEMBL3098610 | 0.87 | CHRNB4 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 | |
| SCHEMBL13096994 | 0.85 | CHRNB4 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 | |
| SCHEMBL13097028 | 0.83 | CNR2 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 | |
| SCHEMBL13097002 | 0.83 | MAOB (0.47) | CNR2CNR1CYP2D6MAOB | |
| SCHEMBL13107194 | 0.83 | ALDH1A1 (0.45) | CYP2D6 | |
| SCHEMBL17534232 | 0.76 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 | |
| SCHEMBL16902845 | 0.76 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 | |
| SCHEMBL29639202 | 0.76 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 | |
| SCHEMBL1470185 | 0.75 | CHRNB2 (0.69) | CHRNB4CHRNA3CHRNB2CHRNA4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | US | disclosed |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2194044-A1 | QUINOLONE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256113-A1 | QUINOLONE DERIVATIVE | NQO1, NQO2, NADK | CHRNB4 2379/4885CHRNA3 1986/4885CHRNB2 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.