Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 5/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3055218 | 0.84 | CDC7 (0.39) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL13086587 | 0.82 | CCNB2 (0.42) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL3060430 | 0.81 | CCNB2 (0.44) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL3060166 | 0.81 | PARP1 (0.43) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL13086468 | 0.80 | MAP2K1 (0.45) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL2791695 | 0.80 | CHEK1 (0.43) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL3063796 | 0.79 | PARP1 (0.41) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL7903645 | 0.77 | CCNB2 (0.39) | PARP1TNKSTNKS2CCNB2CDK1 | |
| SCHEMBL2778486 | 0.77 | LMNA (0.46) | PARP1TNKSTNKS2LMNAHTR1A | |
| SCHEMBL2782117 | 0.75 | PARP1 (0.39) | PARP1TNKSTNKS2GSK3BPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261706-A1 | SUBSTITUTED TETRACYCLIC 1H-INDENO [1,2-B]PYRIDINE-2(5H)-ONE ANALOGS THEREOF AND USES THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261706-A1 | SUBSTITUTED TETRACYCLIC 1H-INDENO [1,2-B]PYRIDINE-2(5H)-ONE ANALOGS THEREOF AND USES THEREOF | TNNI3, TNNT2, ALDH1A2 | PARP1 245/4885TNKS 780/4885TNKS2 1335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.