Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 7/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.43 |
| ▸ | ACHE | P22303 | 8/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786436 | 1.00 | ALDH1A1 (0.44) | ALDH1A1LMNAKDM4EGAAHPGD | |
| SCHEMBL6077071 | 0.98 | LMNA (0.45) | ALDH1A1LMNAKDM4EGAAHPGD | |
| SCHEMBL14529153 | 0.85 | BCHE (0.48) | ALDH1A1LMNAKDM4EGAAHPGD | |
| SCHEMBL6076226 | 0.83 | ALDH1A1 (0.43) | ALDH1A1LMNAKDM4EGAAHPGD | |
| SCHEMBL779243 | 0.81 | CYP1A2 (0.41) | ALDH1A1LMNAKDM4EBCHEACHE | |
| SCHEMBL6076612 | 0.80 | ACHE (0.46) | ALDH1A1HPGDMAPTBCHEGRIN1 | |
| SCHEMBL3111466 | 0.80 | CYP1A2 (0.41) | ALDH1A1LMNAKDM4EACHETSHR | |
| SCHEMBL2624086 | 0.79 | LMNA (0.56) | ALDH1A1LMNAKDM4EBCHEGRIN1 | |
| SCHEMBL785993 | 0.77 | CYP1A2 (0.41) | ALDH1A1LMNAKDM4EACHETSHR | |
| SCHEMBL2273843 | 0.76 | LMNA (0.52) | ALDH1A1LMNAKDM4EBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256170-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100256170-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256170-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, CDK3, GSK3A | ALDH1A1 4625/4885LMNA 4218/4885KDM4E 1621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.