Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312725 | 0.87 | CASP3 (0.48) | EGFRALDH1A1CYP3A4SMN1; SMN2MAPT | |
| SCHEMBL1309884 | 0.85 | ADORA3 (0.49) | ALDH1A1MAPTKDM4ERAB9AHPGD | |
| SCHEMBL1309556 | 0.85 | CYP3A4 (0.52) | NTRK1NTRK2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL1310352 | 0.84 | ABCB1 (0.51) | ALDH1A1CYP3A4SMN1; SMN2MAPTKDM4E | |
| SCHEMBL1312198 | 0.83 | AR (0.44) | MAPTCYP1A2MAOBTNKSCYP1A1 | |
| SCHEMBL1310144 | 0.83 | PTGES (0.50) | EGFRALDH1A1CYP3A4SMN1; SMN2MAPT | |
| SCHEMBL1309569 | 0.82 | CYP3A4 (0.46) | ALDH1A1CYP3A4SMN1; SMN2MAPTKDM4E | |
| SCHEMBL1312794 | 0.81 | ALDH2 (0.38) | ALDH1A1CYP3A4MAPTKDM4ENPC1 | |
| SCHEMBL1312728 | 0.80 | ABCB1 (0.53) | ALDH1A1CYP3A4MAPTKDM4ENPC1 | |
| SCHEMBL1311018 | 0.78 | ALDH2 (0.40) | ALDH1A1CYP3A4KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275707-A1 | SUBSTITUTED AFPO (6-ARYL-4H-FURO[3,2-C]PYRAN-4-ONE) DERIVATIVES AS ANTI-CANCER AGENTS | LEE KUO-HSIUNG | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275707-A1 | SUBSTITUTED AFPO (6-ARYL-4H-FURO[3,2-C]PYRAN-4-ONE) DERIVATIVES AS ANTI-CANCER AGENTS | TP53, FOLR1, THPO | EGFR 312/4885NTRK1 3634/4885NTRK2 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.