Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13101431 | 0.79 | NOTUM (0.37) | NOTUMALDH1A1MAPK1 | |
| SCHEMBL13101432 | 0.75 | CYP2A6 (0.38) | NOTUMHSD11B1CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL197671 | 0.70 | HSD11B1 (0.56) | NOTUMHSD11B1PSMB8CYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL29010139 | 0.68 | HSD11B1 (0.54) | NOTUMHSD11B1PSMB8CYP3A4CYP1A2 | |
| SCHEMBL8022901 | 0.68 | HSD11B1 (0.54) | NOTUMHSD11B1PSMB8CYP3A4CYP1A2 | |
| SCHEMBL8390213 | 0.67 | NOTUM (0.44) | NOTUMHSD11B1PSMB8CYP3A4CYP1A2 | |
| SCHEMBL8042676 | 0.67 | HSD11B1 (0.42) | NOTUMHSD11B1PSMB8CYP3A4CYP1A2 | |
| SCHEMBL29265404 | 0.66 | HSD11B1 (0.44) | NOTUMHSD11B1PSMB8CYP3A4CYP1A2 | |
| SCHEMBL6344165 | 0.64 | PIK3R1 (0.50) | NOTUMHSD11B1CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL10367247 | 0.64 | S1PR1 (0.49) | NOTUMHSD11B1CYP3A4CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256109-A1 | Azetidines As EP2 Antagonists | SKERRATT SARAH ELIZABETH | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256109-A1 | Azetidines As EP2 Antagonists | PTGER2, PTGER1, PTGDR2 | NOTUM 3650/4885HSD11B1 802/4885PSMB8 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.