Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102260 | 0.93 | KDM4E (0.47) | KDM4ECSNK1DHTR1ADRD2HTR2A | |
| SCHEMBL13102358 | 0.92 | HTR7 (0.42) | KDM4EHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL13102209 | 0.92 | TRPV1 (0.39) | KDM4ECSNK1DTRPV1HTR1ADRD2 | |
| SCHEMBL13102018 | 0.91 | NPSR1 (0.48) | KDM4ECSNK1DLMNANPSR1ALDH1A1 | |
| SCHEMBL13102109 | 0.90 | LMNA (0.43) | KDM4ETRPV1HTR7LMNANPSR1 | |
| SCHEMBL13102007 | 0.90 | HDAC6 (0.43) | CSNK1DHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL13102008 | 0.88 | ALDH1A1 (0.39) | KDM4ECSNK1DLMNANPSR1ALDH1A1 | |
| SCHEMBL13102278 | 0.88 | ALDH1A1 (0.42) | HTR1ADRD2HTR2AHTR2CHTR7 | |
| SCHEMBL13102193 | 0.88 | CSNK1D (0.45) | KDM4ECSNK1DFFAR2LMNAALDH1A1 | |
| SCHEMBL13101676 | 0.86 | ALDH1A1 (0.42) | CSNK1DTRPV1LMNANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329713-B2 | Fused ring heterocycles as potassium channel modulators | ICAGEN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20100273784-A1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273784-A1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | KCNK17, KCNJ2, KCNJ1 | KDM4E 1397/4885CSNK1D 2550/4885TRPV1 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.