Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312684 | 0.79 | KDM4E (0.37) | KDM4EALDH1A1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL1311606 | 0.74 | GAA (0.41) | KDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1310608 | 0.72 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL28871770 | 0.68 | GAA (0.69) | HTTKDM4EALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL31006493 | 0.68 | GAA (0.69) | HTTKDM4EALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL5361880 | 0.68 | HDAC1 (0.74) | ALDH1A1SMN1; SMN2CYP2C19GAAKMT2A | |
| SCHEMBL1312899 | 0.67 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2MAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL1147720 | 0.67 | POLB (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL11832072 | 0.65 | PTGS2 (0.68) | ALDH1A1CYP2C19GAAHDAC1HDAC6 | |
| SCHEMBL31006498 | 0.65 | PTGS2 (0.68) | ALDH1A1CYP2C19GAAHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275646-A1 | Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275646-A1 | Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function | VEGFA, TEK, LIPG | HTT 2227/4885KDM4E 3815/4885ALDH1A1 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.