Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.31 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.30 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.30 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24208232 | 0.87 | CHRNB2 (0.35) | DPP4LIPECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL22791097 | 0.87 | CHRNB2 (0.35) | DPP4LIPECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL19116482 | 0.87 | CHRNB2 (0.35) | DPP4LIPECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL21569357 | 0.81 | CHRNB2 (0.34) | DPP4LIPECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL11890354 | 0.79 | PDK1 (0.37) | DPP4LIPECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL22802723 | 0.79 | LIPE (0.36) | DPP4LIPECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL21386688 | 0.77 | DPP4 (0.38) | DPP4LIPECYP3A4FAAH | |
| SCHEMBL23518450 | 0.77 | CHRNB2 (0.44) | DPP4LIPECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL12720521 | 0.76 | POLB (0.38) | LIPECHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL22900046 | 0.75 | CHRNB2 (0.35) | DPP4LIPECHRNB2CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |