Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 5/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13263305 | 0.88 | NPY5R (0.48) | CYP19A1NPY5RKDM4ENPC1RAB9A | |
| SCHEMBL13115243 | 0.87 | NPY5R (0.57) | CYP19A1NPY5RKDM4ENPC1RAB9A | |
| SCHEMBL13115339 | 0.85 | MAPK13 (0.56) | CYP19A1KDM4EALDH1A1HPGDMAPK13 | |
| SCHEMBL13115328 | 0.84 | CYP11B2 (0.54) | CYP19A1NPY5RKDM4EALDH1A1MAPK13 | |
| SCHEMBL7367947 | 0.82 | NPY5R (0.63) | CYP19A1NPY5RKDM4ENPC1RAB9A | |
| SCHEMBL13115247 | 0.82 | NPY5R (0.51) | NPY5RKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL13115331 | 0.82 | BRAF (0.42) | CYP19A1NPY5RKDM4ENPC1RAB9A | |
| SCHEMBL13115246 | 0.80 | CYP2A6 (0.56) | CYP19A1NPY5RKDM4ENPC1RAB9A | |
| SCHEMBL13115353 | 0.80 | DYRK1A (0.46) | CYP19A1NPY5RKDM4ENPC1RAB9A | |
| SCHEMBL7370361 | 0.79 | TLR8 (0.59) | NPY5RKDM4ENPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | HONGU MITSUYA | 2010-10-07 | — | — | US | disclosed |
| US-7759373-B2 | Large conductance calcium-activated K channel opener | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | KCNN3, KCNN2, KCNN1 | CYP19A1 3716/4885NPY5R 695/4885KDM4E 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.