Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 16/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.61 |
| ▸ | GCGR | P47871 | 14/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.61 |
| ▸ | FRK | P42685 | 4/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.61 |
| ▸ | GSK3B | P49841 | 4/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.61 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 13/20 | 0.56 |
| ▸ | PRKACA | P17612 | 3/20 | 0.54 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13115389 | 0.93 | MAPK11 (0.49) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13115392 | 0.87 | MAPK14 (0.53) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13115406 | 0.84 | CYP11B1 (0.48) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13137669 | 0.84 | ALOX5 (0.44) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13115397 | 0.84 | ALOX5 (0.58) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13115395 | 0.84 | MAPK14 (0.58) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13138374 | 0.83 | MAPK14 (0.57) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13115410 | 0.83 | MAPK11 (0.41) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13115554 | 0.83 | MAPK13 (0.41) | MAPK11MAPK14MAPK13MAPK12GCGR | |
| SCHEMBL13137171 | 0.82 | ALOX5 (0.46) | MAPK11MAPK14MAPK13MAPK12GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | HONGU MITSUYA | 2010-10-07 | — | — | US | disclosed |
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | HONGU MITSUYA | 2010-10-07 | — | — | US | disclosed |
| US-7759373-B2 | Large conductance calcium-activated K channel opener | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-20 | — | — | US | disclosed |
| US-7759373-B2 | Large conductance calcium-activated K channel opener | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | KCNN3, KCNN2, KCNN1 | MAPK11 2136/4885MAPK14 1232/4885MAPK13 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.