Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.58 |
| ▸ | TCF4 | P15884 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.42 |
| ▸ | GCGR | P47871 | 4/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13115389 | 0.90 | MAPK11 (0.49) | ALOX5MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL13115392 | 0.85 | MAPK14 (0.53) | ALOX5NOX1MAPK13GCGRMAPK12 | |
| SCHEMBL13115404 | 0.84 | MAPK11 (0.61) | ALOX5MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL13115395 | 0.82 | MAPK14 (0.58) | ALOX5MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL13137669 | 0.82 | ALOX5 (0.44) | ALOX5MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL13115410 | 0.81 | MAPK11 (0.41) | ALOX5MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL13138374 | 0.81 | MAPK14 (0.57) | ALOX5MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL13137171 | 0.80 | ALOX5 (0.46) | ALOX5MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL5622957 | 0.79 | ALOX5 (0.87) | ALOX5TCF4CTNNB1NOX1MAPK13 | |
| SCHEMBL13115417 | 0.79 | MAPK14 (0.45) | ALOX5MAPK13GCGRMAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | HONGU MITSUYA | 2010-10-07 | — | — | US | disclosed |
| US-7759373-B2 | Large conductance calcium-activated K channel opener | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | KCNN3, KCNN2, KCNN1 | ALOX5 2112/4885TCF4 4018/4885CTNNB1 2621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.