Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | GHSR | Q92847 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1311622 | 0.89 | CXCR1 (0.62) | CA12CA9CA1POLBKMT2A | |
| SCHEMBL1311670 | 0.83 | LMNA (0.59) | CA12CA9CA1POLBKMT2A | |
| SCHEMBL12112980 | 0.83 | KMT2A (0.62) | CA12CA9CA1POLBKMT2A | |
| SCHEMBL12113101 | 0.80 | GHSR (0.53) | CA12CA9CA1GHSRKMT2A | |
| SCHEMBL4388940 | 0.78 | CXCR2 (0.78) | CA12CA9CA1POLBKMT2A | |
| SCHEMBL1311644 | 0.76 | CA12 (0.54) | CA12CA9CA1POLBCXCR1 | |
| SCHEMBL11332310 | 0.76 | KMT2A (0.73) | CA12CA9CA1POLBKMT2A | |
| SCHEMBL5852169 | 0.76 | LMNA (0.68) | CA12CA9CA1POLBKMT2A | |
| SCHEMBL12010876 | 0.75 | MEN1 (0.72) | CA12CA9CA1GHSRKMT2A | |
| SCHEMBL1314971 | 0.75 | MAPT (0.57) | POLBKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275635-A1 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2011-11-10 | — | — | US | disclosed |
| WO-2010123591-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275635-A1 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | NAMPT, NAPRT, NNT | CA12 4486/4885CA9 3562/4885CA1 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.