Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120792 | 0.82 | L3MBTL1 (0.40) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13120795 | 0.82 | HTT (0.43) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8496285 | 0.81 | AR (0.39) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29958183 | 0.80 | L3MBTL1 (0.38) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8495853 | 0.73 | CETP (0.47) | KDM4ELMNAALOX12POLBALDH1A1 | |
| SCHEMBL28282824 | 0.73 | CSNK2A1 (0.35) | CSNK2A1HIPK2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16377909 | 0.71 | KDM4E (0.39) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22500987 | 0.70 | TOP2A (0.48) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18347806 | 0.69 | MEN1 (0.49) | MAPTHSD17B10KDM4ELMNAALDH1A1 | |
| SCHEMBL31358248 | 0.69 | CYP3A4 (0.41) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |