Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937539 | 0.84 | ATR (0.47) | KDM4ERAB9A | |
| SCHEMBL16856823 | 0.82 | LMNA (0.44) | KDM4ELMNATOP2AL3MBTL1CETP | |
| SCHEMBL7125030 | 0.81 | L3MBTL1 (0.41) | KDM4ELMNATOP2AL3MBTL1CETP | |
| SCHEMBL29956074 | 0.78 | KDM4E (0.39) | KDM4ELMNATOP2AL3MBTL1ALOX12 | |
| SCHEMBL16857151 | 0.78 | TOP2A (0.38) | KDM4ELMNATOP2AL3MBTL1CETP | |
| SCHEMBL16857291 | 0.78 | TOP2A (0.38) | KDM4ELMNATOP2AL3MBTL1CETP | |
| SCHEMBL29958183 | 0.78 | L3MBTL1 (0.38) | KDM4ELMNATOP2AL3MBTL1ALOX12 | |
| SCHEMBL16856956 | 0.77 | TOP2A (0.38) | KDM4ELMNATOP2AL3MBTL1CETP | |
| SCHEMBL8495853 | 0.77 | CETP (0.47) | KDM4ELMNAALOX12CETPPOLB | |
| SCHEMBL16857100 | 0.76 | TMIGD3 (0.39) | KDM4ELMNATOP2AL3MBTL1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567040-B1 | METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES | AMGEN INC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3567040-A1 | METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES | Amgen, Inc (US) | 2019-11-13 | — | — | EP | disclosed |
| EP-3013825-B1 | METHOD FOR THE PREPARATION OF (1,2,4)-TRIAZOLO(4,3-A)PYRIDINES | AMGEN INC (US) | 2019-08-07 | — | — | EP | disclosed |
| US-9643984-B2 | Method for the preparation of [1,2,4]-triazolo[4,3-a]pyridines | AMGEN INC. (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643984-B2 | Method for the preparation of [1,2,4]-triazolo[4,3-a]pyridines | AMGEN INC. (US) | 2017-05-09 | — | — | US | disclosed |
| US-20160347769-A1 | METHOD FOR THE PREPARATION OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES | AMGEN INC. | 2016-12-01 | — | — | US | disclosed |
| US-20160347769-A1 | METHOD FOR THE PREPARATION OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES | AMGEN INC. | 2016-12-01 | — | — | US | disclosed |
| WO-2014210042-A2 | METHOD FOR THE PREPARATION OF (1,2,4)-TRIAZOLO(4,3-A)PYRIDINES | AMGEN INC. (US) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347769-A1 | METHOD FOR THE PREPARATION OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES | H1-4, H1-5, H1-3 | KDM4E 452/4885LMNA 462/4885TOP2A 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.