Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450577 | 0.79 | TUBB4A (0.47) | SYKCDK1CDK4CCNB1CCND1 | |
| SCHEMBL3450774 | 0.73 | MEN1 (0.50) | SYKCDK1CDK2CDK5PIK3CA | |
| SCHEMBL14302762 | 0.71 | RAB9A (0.53) | — | |
| SCHEMBL3450235 | 0.71 | BCL6 (0.46) | SYKADORA1ADORA2AITKKDM4E | |
| SCHEMBL3452140 | 0.69 | PIK3CA (0.56) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL13127047 | 0.69 | VCP (0.48) | SYKVCPADORA1ADORA2AMERTK | |
| SCHEMBL3451258 | 0.68 | CDC7 (0.58) | SYKCDK1CDK2CDK5ADORA1 | |
| SCHEMBL13110714 | 0.68 | BCL6 (0.54) | VCPMERTKKDM4E | |
| SCHEMBL3229491 | 0.68 | VCP (0.49) | SYKVCPADORA1ADORA2AMERTK | |
| SCHEMBL3228814 | 0.68 | VCP (0.52) | SYKVCPADORA1ADORA2AMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | disclosed |