Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011050 | 0.90 | RAB9A (0.67) | RAB9AKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL10137686 | 0.84 | RAB9A (0.74) | RAB9AKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL396078 | 0.83 | NPSR1 (0.62) | RAB9AKMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL30822851 | 0.82 | RAB9A (0.71) | RAB9AKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL312910 | 0.81 | TDP1 (0.81) | RAB9AKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL20442339 | 0.81 | RAB9A (0.78) | RAB9AKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL27337757 | 0.80 | KMT2A (0.69) | RAB9AKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL27471805 | 0.80 | RAB9A (0.76) | RAB9AKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL30444042 | 0.79 | RAB9A (0.59) | RAB9AKMT2AHTTNPC1ALDH1A1 | |
| SCHEMBL13831592 | 0.79 | RAB9A (0.59) | RAB9AKMT2AHTTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130243727-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-20130243727-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-8450350-B2 | Triazoles as inhibitors of fatty acid synthase | INFINITY PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450350-B2 | Triazoles as inhibitors of fatty acid synthase | INFINITY PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| WO-2011140296-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | Infinity Pharmaceuticals (US) | 2011-11-10 | — | — | WO | disclosed |
| US-20110274654-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS INC. | 2011-11-10 | — | — | US | disclosed |
| US-20110274654-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS INC. | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130243727-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | FASN, SCD, FADS1 | RAB9A 2813/4885KMT2A 3529/4885TDP1 2863/4885 |
| US-20110274654-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | FASN, SCD, FADS1 | RAB9A 2813/4885KMT2A 3529/4885TDP1 2863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.